ДИНАМИКА ЕСТЕСТВЕННОГО БИОРАСПРЕДЕЛЕНИЯ МАГНИТНЫХ НАНОЧАСТИЦ, ПОЛУЧЕННЫХ РАЗЛИЧНЫМИ СПОСОБАМИ, ПРИ ИХ ОДНОКРАТНОМ ВВЕДЕНИИ КРЫСАМ СТОКА WISTAR

The method of quantitative determination of iron content was used to investigate the dynamics of the natural biodistribution of magnetic nanoparticles of various structure and composition when a single intravenous administration to Wistar rats. The results indicate that entered into the body magnetic nanoparticles of various synthesis technique demonstrate the distribution dynamics of mixed trends. Probably the dynamics of the natural distribution of nanoparticles is influenced by factors determined by the terms of nanoparticles synthesis. The characteristics of the nanoparticles produced with various synthesis methods presumably have an impact not only on their natural biodistribution in the body but also on the tropism for specific tissues and organs, thereby determining the range of possible use in biomedicine.