ALZHEİMER VE VASKÜLER DEMANSLI HASTALARDA LİPİD PROFİLİ İLE YAĞDA ERİYEN VİTAMİNLERİN DEĞERLENDİRİLMESİ The Evaluation Of Fat Soluble Vitamins and Lipids Among Patients With Alzheimer and Vascular Dementia

OZET Amac: Bu calismada, Alzheimer Demans (AD) ve Vaskuler demans (VaD)’li hastalarda serum lipid duzeyleri ile yagda eriyen vitamin duzeylerinin demans ile iliskilerinin incelenmesi amaclanmistir. Gerec ve Yontemler: Calismaya uluslarasi kriterlere gore tanilari konulmus 60 AD, 52 VaD hastasi ile 61 kontrol vakasi alindi. Serum lipid profilleri ve yagda eriyen vitamin duzeyleri (D, K) calisildi. Bulgular: Serum D vitamini degerleri AD ve VaD hasta gruplarinda, kontrol grubuna gore daha dusuk bulundu. Vitamin K acisindan ise anlamli bir fark gorulmedi. Gruplarin lipid profilleri incelendiginde total kolesterol( TK) degerlerinin, her iki hasta grubunda kontrol grubuna gore daha yuksek oldugu saptandi. Kontrol grubunda, TK ile D vitamini arasinda negatif bir iliski gozlendi. Hasta gruplarinda D vitamini ile ve tum gruplarda K vitamini ile lipidler arasinda bir iliski bulunmadi. Yuksek dansiteli lipoprotein (HDL), trigliserid (TG) ve dusuk dansiteli lipoprotein (LDL) degerleri acisindan hasta gruplari ve kontrol grubu arasinda fark bulunmadi. Sonuc: Vitamin D dusuklugu ile TK yuksekligi AD ve VaD hastaligi ile birliktelik gostermektedir. Bu iki demans tipi arasinda bu parametreler acisindan bir fark saptanmamistir. Saglikli kontrol vakalarinda vitamin D ile TK arasinda saptanan ters iliski demans hastalarinda gozlenmemistir. Verilerimiz; demans hastalarinda, vitamin D ve TK iliskisinin daha ayrintili incelenmesinin gerektigini ortaya koymaktadir. Anahtar Kelimeler: Alzheimer; Vaskuler Demans; Vitamin D; K; Lipidler ABSTRACT Objective: The aim of this study is to determine whether serum lipid levels and fat soluble vitamin levels of the patients who suffer from Alzheimer’s Dementia (AD) and Vascular Dementia (VaD) is different from the healthy control group and to examine the relation of these parameters with dementia. Material and Methods: Sixty AD patients and 52 VaD patients who were diagnosed according to international criteria and 61 control cases whose ages and sexes were compatible in general were taken to the study. Serum lipid profiles and fat soluble vitamin levels (vitamin D and vitamin K) were studied. Results: Serum vitamin D values at the AD and VaD patient groups was found significantly lower than the control group (p = 0.001). No significant difference was determined with vitamin K values. When the lipid profiles of the groups were analyzed, total cholesterol values were determined significantly higher at the two patient groups than the control group (p = 0.001). Moreover, a significantly negative relationship between total cholesterol and vitamin D was observed at the control group (p < 0.005). No relationship in patient groups for vitamin D and in all groups for vitamin K was found. No difference between the patient groups and control groups in terms of high density lipoprotein, triglyceride and low density lipoprotein values was found. Conclusion: This study is showed that Vitamin D deficiency and high total cholesterol are associated with AD and VaD disease. There is no difference between these two dementia types in terms of these parameters. Moreover, the inverse relation determined between vitamin D and total cholesterol at healthy control cases is not observed at the dementia patients. All these suggests that a detailed analysis of the relation between vitamin D and total cholesterol and dementia will be useful. Keywords: Alzheimer; Vascular Dementia; Vitamin D; K; Lipids.