Inhibition Effect of NIR Photothermal Therapy Mediated by Gold Nanoflowers on Proliferation of Human Laryngocarcinoma Hep-2 Cells

Citrate-capped gold nanoflowers(GNFs) prepared by seeding approach were identified to show efficiently photothermal conversion under the irradiation of 808 nm near-infrared laser.MTT[3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] results demonstrate that the photothermal therapy mediated by GNFs inhibits the proliferation of Hep-2 cells effectively,and the inhibition effect increases with the increased concentrations of GNFs and power of the laser.The results of apoptosis and necrosis tested by flow cytometry demonstrate that the photothermal ablation play a predominant role in suppressing the proliferation of the Hep-2 cells.Such citrate-capped GNFs are expected to be a kind of materials potential useful in tumuor NIR photothermal therapy.