Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia

Martin Satny,Veronika Todorovova,Tereza Altschmiedova,Jaroslav A. Hubacek,Lucie Dlouha,Vera Lanska,Vladimir Soska,Ondrej Kyselak,Tomas Freiberger,Martin Bobak,Michal Vrablik

Journal of clinical lipidology（2023）

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摘要

•5 % of APOE2/E2 homozygotes develop familial dysbetalipoproteinemia (FD).•several gene SNPs are individual additive factors influencing FD development.•unweighted GRS2 is a clinically relevant tool that improves the prediction of FD.

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关键词

Familial dysbetalipoproteinemia,Cardiovascular risk,Polymorphism,Genetic risk score

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