Towards the crux of sex-dependent variability in red cell concentrates
Transfusion and Apheresis Science(2023)
摘要
Donor sex can alter the RBC 'storage lesion' progression, contributing to dissimilarities in blood product quality, and thus adverse post-transfusion reactions. The mechanisms underlying the reduced sensitivity of female RBCs to storage-induced stress are partially ascribed to the differential effects of testosterone, progesterone, and estrogen on hemolytic propensity. Contributing to this is the increased proportion of more robust, biologically 'young' subpopulations of RBCs in females. Herein, we discuss the impact of sex hormones on RBCs and the relevance of these biological subpopulations to provide further insight into sex-dependent blood product variability.
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关键词
Red blood cells,Adverse transfusion reactions,Sex -mismatched transfusion reactions,Sex hormones,Storage lesion,Donor variation effect
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