Process development for pilot-scale spray drying of ultrasmall iron (oxyhydr)oxide nanoparticles
POWDER TECHNOLOGY(2024)
摘要
In manufacturing iron (oxyhydr)oxide nanoparticles, drying is often necessary to increase stability or to enable granulation and tableting. Lyophilization is a simple drying method, although it is characterized by high energy consumption and high cost. This study aims to demonstrate that spray drying is a suitable alternative for preparing iron (oxyhydr)oxide nanoparticles. A Design of Experiment approach was used varying the inlet air temperature, feed flow rate, and feed concentration. Especially a low feed flow rate was beneficial for low residual moisture (< 7%) and high yield (> 80%). The process was subsequently transferred to pilot scale at a feed flow rate of 2.3 kg/h. The nanomaterial had comparable properties and efficacy to the freeze-dried product. However, about 15% lower yield and 35% lower energy consumption were found for spray drying the nanoparticles. This study shows that spray drying is a suitable alternative to freeze drying for iron (oxyhydr)oxide nanoparticles.
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关键词
Ferrihydrite,Freeze-drying,Design of experiments,DoE,Lyophilization,Spry-drying
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