Cell mechanics in early vertebrate development: Yap mechanotransduction controls notochord formation and neural tube patterning

A recent study published in Science Advances1 showed the influence of Yap on notochord formation and NT (neural tube) patterning in vertebrate embryonic development, and conducted an in-depth study from the perspective of biomechanical signal mechanotransduction. In addition, this study also explored the possible complex interaction between mechanical signals and gene expression. Together, this study provides new insights into the development mechanism of early vertebrate embryos.