Hierarchical porous covalent organic framework-based sensor for the detection of neurodegenerative disorder biomarkers

Guanosine is an essential biomarker that enacts an important role in neuroprotection against brain-related activities, influences the metabolism of fatty acids, and assists in the improvement of the gastrointestinal tract. A facile and selective electrochemical sensor has been developed for the sensing of guanosine based on a hierarchical porous covalent organic framework. Owing to the distinctive 2D porous architecture and ordered framework of TpBD-COF, the irreversible electrooxidation of guanosine occurred at 1.03 V (vs. SCE) in phosphate buffer solution at pH 6. The anodic peak currents under optimal conditions were linear with guanosine concentration within the range of 0.123-720 mu M with a LOD of 40.63 nM under various optimal conditions. Moreover, the developed biosensor was used to determine guanosine in pharmaceutical tablets to confirm its potential application in the healthcare industry.