Supplementary Figure S1 from Autocrine 17-β-Estradiol/Estrogen Receptor-α Loop Determines the Response to Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer

Outcome of non-small cell lung cancer patients, disaggregated according to gender, PD-L1 and ERα levels. Best response (PD: progressive disease; PR: partial response; SD: stable disease) after 6 months from the beginning of pembrolizumab treatment as first-line monotherapy, PFS and OS (Kapan-Meier and log-rank test) were analyzed in 35 NSCLC patients (15 females; 20 males). a-c. Female (F) and male (M) patients were stratified in CD274/PD-L1low and CD274/PD-L1high, according to the median value of the CD274/PD-L1mRNA, measured by RT-PCR in the tumor samples (technical triplicates). d-f. F and M patients were stratified in ESR1/ERαlow and ESR1/ERαhigh, according to the median value of the ESR1/ERα mRNA, measured by RT-PCR in the tumor samples (technical triplicates).