Platelet ceramides drive thrombo-inflammation in aortic aneurysm formation
Nature Cardiovascular Research(2023)
摘要
Effective pharmacological treatment options for abdominal aortic aneurysm (AAA) are missing. A study by Zhang et al. suggests that targeting the thrombo-inflammatory activity of platelets by blocking the intracellular accumulation of ceramides might limit AAA progression while not affecting hemostatic platelet function.
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