Spontaneous regression of metastatic renal cancer and improvement in IMDC risk criteria prior to cytoreductive nephrectomy

A 57-year-old male presented with a 2-month history of a cough, weight loss, chest discomfort and night sweats. He was diagnosed with poor prognosis metastatic Renal Cancer (RCC) according to International Metastatic RCC Database Consortium (IMDC) criteria. We observed spontaneous regression of his metastatic disease and concurrent improvement in his IMDC risk stratification. This changed the initial recommendation of the MDT, and the patient elected to undergo cytoreductive nephrectomy (CRN) with the expectation he would need deferred systemic treatment. He made an uneventful post-operative recovery and at 12 months his follow-up imaging continues to show resolution of his metastatic disease.