Development of novel liver-targeting glucocorticoid prodrugs

Yazheng Wang,Dandan Guo,Rebecca Winkler,Xiaohong Lei,Xiaojing Wang,Jennifer Messina,Juntao Luo,Hong Lu

Medicine in Drug Discovery（2024）

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摘要

•Ultra-hydrophilic zwitterionic linker markedly increased prodrug water solubility.•Liver-targeting dexamethasone prodrug had less suppressive effects on immune cells.•Liver-targeting dexamethasone prodrug had stronger hepatic antiinflammatory effects.

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关键词

Glucocorticoid receptor,Alcoholic hepatitis,Sepsis,Liver-specific,Prodrug,Zwitterionic linker

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