Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy
SEMINARS IN IMMUNOLOGY(2024)
摘要
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in shaping adaptive immunity. DCs have a unique ability to sample their environment, capture and process exogenous antigens into peptides that are then loaded onto major histocompatibility complex class I molecules for presentation to CD8(+) T cells. This process, called cross-presentation, is essential for initiating and regulating CD8(+) T cell responses against tumors and intracellular pathogens. In this review, we will discuss the role of DCs in cancer immunity, the molecular mechanisms underlying antigen cross-presentation by DCs, the immunosuppressive factors that limit the efficiency of this process in cancer, and approaches to overcome DC dysfunction and therapeutically promote antitumoral immunity.
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关键词
Dendritic cell,Cross-presentation,Tumor,Vaccine,FLT3L,Immunotherapy
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