Cryptic-site-specific Antibodies to the SARS-CoV-2 Receptor Binding Domain Can Retain Functional Binding Affinity to Spike Variants

Kan Li,Richard H. C. Huntwork,Gillian Q. Horn,Milite Abraha,Kathryn M. Hastie,Haoyang Li,Vamseedhar Rayaprolu,Eduardo Olmedillas,Elizabeth Feeney,Kenneth Cronin,Sharon L. Schendel,Mark Heise,Daniel Bedinger,Melissa D. Mattocks,Ralph S. Baric,S. Munir Alam,Erica Ollmann Saphire,Georgia D. Tomaras,S. Moses Dennison

JOURNAL OF VIROLOGY（2023）

Cited 0|Views30

Key words

SARS-CoV-2,COVID-19,RBD,binding kinetics,epitope binning,monoclonal antibodies,neutralizing antibodies,surface plasmon resonance,biolayer interferometry,ACE-2 blocking

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