Genomic Characterization of Methicillin-Susceptible Staphylococcus aureus Carriage in Patients on Home Parenteral Nutrition and Their Caregivers

Michelle Gompelman,Ingrid J. M. van Weerdenburg,Guus T. J. Wezendonk,Jordy P. M. Coolen,Reinier P. Akkermans,Chantal P. Rovers,Heiman F. L. Wertheim,Geert J. A. Wanten

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

In this prospective study, patients on home parenteral nutrition were twice as likely to be colonized with Staphylococcus aureus if their caregivers were carriers. Among S. aureus-positive patients and their caregivers, molecular analysis showed 68% genetically related strains. Despite decolonization, genetically related strains reappeared in 70% of patients.

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Staphylococcus aureus carriage,home parenteral nutrition,transmission,whole-genome sequencing,decolonization treatment

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