Noninvasive Characterization of Tissue Microvessel Architecture in MRI

Noninvasive determination of microvessel architecture is important in oncology, but has never been shown. Here, new parameters describing the microvessel architecture based on perfusion MRI are introduced and a flow phantom is created to evaluate them. Two different MRI perfusion methods were used for describing the microvessel architecture, and the result parameters were evaluated on phantom data and illustrated on in vivo preclinical data.