14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2. Marcel S Woo , Johanna Nilsson , Joseph Therriault , Nesrine Rahmouni , Ann Brinkmalm , Andrea L Benedet , Nicholas J Ashton , Arthur C Macedo , Stijn Servaes , Yi-Ting Wang , Cécile Tissot , Jaime Fernandez Arias , Seyyed Ali Hosseini , Mira Chamoun , Firoza Z Lussier , Thomas K Karikari , Jenna Stevenson , Christina Mayer , João Pedro Ferrari-Souza , Eliane Kobayashi , Gassan Massarweh , Manuel A Friese , Tharick A Pascoal , Serge Gauthier , Henrik Zetterberg , Kaj Blennow , Pedro Rosa-Neto Journal of neuroinflammation（2023）
摘要
Our results advertise that sTREM2 is mediating synaptic injury at the early stages of tau accumulation, underlining the importance of microglia activation for AD disease propagation.
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