Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells
CHEMICAL COMMUNICATIONS(2023)
摘要
Elevated GSH and H2O2 in cancer cells is sometimes doubted due to their contrary reactivities. Here, we construct a dual-responsive fluorescent probe to confirm the conclusion, and employ this to exploit a redox-inducible DNA interstrand crosslink (ICL) precursor. It crosslinks DNA upon activation by GSH and H2O2, affording an alternative dual-responsive strategy. Elevated GSH and H2O2 in some cancer cells is confirmed, and employed for the development of dual-responsive DNA ICL precursor.
更多查看译文
关键词
cancer cells,unique redox status,dna,dual-responsive
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要