Catalytic System for Cross-Coupling of Heteroaryl Iodides with a Nitronyl Nitroxide Gold Derivative at Room Temperature

A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN-AuPPh3 at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd2(dba)3 center dot CHCl3 and the phosphine ligand MeCgPPh having an adamantane-like framework. The present protocol was found to be well compatible with various heteroaryl iodides, thus opening new horizons in directed synthesis of functionalized nitronyl nitroxides and high-spin molecules.