Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development

Athiramol Sasi,Andreas Romaine,Pugazendhi Murugan Erusappan,Arne Olav Melleby,Almira Hasic,Christen Peder Dahl,Kaspar Broch, Vibeke Marie Almaas,Rosa Doñate Puertas,H. Llewelyn Roderick,Ida Gjervold Lunde,Ivar Sjaastad,Maria Vistnes,Geir Christensen

Matrix Biology Plus（2023）

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摘要

Temporal expression profiles of versican and the DPEAAE fragment during cardiac fibrosis development. The V1 isoform of versican is expressed by collagen-producing fibroblasts early after initiation of pressure overload. Versican is expressed around the vessels before development of perivascular fibrosis. In patients with cardiomyopathies, increased amounts of versican and the DPEAAE fragment were observed in fibrotic regions of the myocardium.

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关键词

cardiac fibrosis development,proteoglycan versican,cardiac fibrosis

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