Isolated small airways obstruction predicts future chronic airflow obstruction: a multinational longitudinal study.

Ben Knox-Brown,James Potts, Valentina Quintero Santofimio,Cosetta Minelli,Jaymini Patel, Najlaa Mohammed Abass,Dhiraj Agarwal,Rana Ahmed,Padukudru Anand Mahesh, Jayaraj Bs,Meriam Denguezli,Frits Franssen,Thorarinn Gislason,Christer Janson,Sanjay K Juvekar,Parvaiz Koul,Andrei Malinovschi,Asaad Ahmed Nafees,Rune Nielsen, Stefanni Nonna M Paraguas,Sonia Buist,Peter Gj Burney,Andre F S Amaral

BMJ Open Respiratory Research（2023）

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摘要

BACKGROUND:Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways obstruction is associated with chronic airflow obstruction later in life. METHODS:We used longitudinal data from 3957 participants of the multinational Burden of Obstructive Lung Disease study. We defined isolated small airways obstruction using the prebronchodilator mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FVC) (FEF25-75) if a result was less than the lower limit of normal (更多

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