MTHFR 677C>T (rsRS1801133) variant is associated with hyperhomocysteinemia but not with clinical severity in patients with peripheral arterial disease.

Guilherme da Silva Silvestre, Iriana Moratto Carrara,Tamires Flauzino,Marcell Alysson Batisti Lozovoy,Rubens Cecchini,Edna Maria Vissoci Reiche,Andréa Name Colado Simão

Jornal Vascular Brasileiro（2023）

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摘要

The T allele of 677C>T variant was associated with higher Hcy levels in PAD patients, but not in controls, suggesting a possible interaction between the 677C>T variant and other genetic, epigenetic, or environmental factors associated with PAD, affecting modulation of Hcy metabolism.

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关键词

peripheral arterial disease,methylenetetrahydrofolate reductase,homocysteine,genetic variant,Fontaine classification

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