Utilization of cefepime therapeutic drug monitoring in febrile neutropenia patients with hematologic malignancies.

Emma F Lodl,Mohammad H Alshaer,C Brooke Adams,Ashley Richards,Charles Peloquin,Veena Venugopalan

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners（2023）

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摘要

This study showed that standard cefepime dosing in patients with hematologic malignancies and FN does not result in achievement of 100% T > MIC in all patients. Patients in the group that did not achieve PK/PD target attainment were younger with increased creatinine clearance, indicating that cefepime TDM may be especially beneficial in these patients.

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