Advances in the Study of Liposomes Gel with Stimulus Responsiveness in Disease Treatment

With the extensive applications of nanomaterials in drug delivery in recent years, nanocarriers with composite polymers, represented by liposomal gels, have been studied for drug delivery for numerous diseases. The drug is loaded inside the liposomal gel and is endowed with specific temperature, pH, enzyme, light, electric field and other stimulating materials; further, the release of the loaded drug is controlled by specific stimuli. Liposomal gels provide better stability for drug formulation and obtaining higher targeting and stimulus responsiveness compared to single nano-drug-loaded materials. Hence, the toxic side effects of drugs can be effectively reduced and the drug delivery efficiency, therapeutic efficacy and safety can be considerably improved. At present, research on liposome gels as drug delivery carriers is still under developing stage, and their advantages as drug carriers will be more useful in practice and become a powerful tool for human beings to cure diseases in the future. In the future studies, the synthesis and stimuli-responsive mechanism of liposomal gels can be further explored to expand their applications in the field of disease treatment and provide more innovative solutions for precision medicine and individualised therapy. This review explores the application of liposome gels with stimuli-responsiveness as drug carriers for treating diseases, the advantages of liposome gels as drug carriers, the methods and principles of their fabrication, the stimuli-responsiveness of liposome gels for targeted release against diseases and its current challenges and opportunities to suggest certain methods and ideas for the development of smarter precision-targeted hybrid nanosystems in the future.