Synthesis of aryl-substituted derivatives of acetogenins using the Ti-catalyzed homo -cyclomagnesiation of 1,2-dienes as a key step
Russian Chemical Bulletin(2023)
摘要
New symmetric aryl-substituted derivatives of acetogenins were synthesized using the Ti-catalyzed homo -cyclomagnesiation of aryl-substituted 1,2-dienes at the key step. Ruthenium catalyzed oxidative cyclization of symmetric aryl-substituted 1 Z ,5 Z -dienes was used to synthesize diols and ketols containing a tetrahydrofuran fragment. Diastereoselective reduction of ketols with L-selectride yielded target diols. In addition, by oxidation of ketols with Dess—Martin periodinane, diketones were synthesized in high yields.
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关键词
homo -cyclomagnesiation
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