Ibrutinib and venetoclax as primary therapy in symptomatic treatment naïve Waldenström macroglobulinemia

Jorge J. Castillo,Andrew R. Branagan, David Sermer,Catherine A. Flynn,Kirsten Meid,Megan Little, Katherine Stockman,Timothy White, Alexa Canning,Maria L. Guerrera,Amanda Kofides,Shirong Liu,Xia Liu,Kris Richardson,Nicholas Tsakmaklis, Christopher J. Patterson,Zachary R. Hunter,Steven P. Treon,Shayna Sarosiek

Blood（2023）

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摘要

•The combination of ibrutinib and venetoclax induced deep and durable responses in treatment naïve Waldenström macroglobulinemia patients.•Planned study therapy was stopped early due to a higher-than-expected occurrence of ventricular arrhythmia in 4 of 45 participants.

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