Vagus nerve stimulation protects against cerebral injury after cardiopulmonary resuscitation by inhibiting inflammation through the TLR4/NF-κB and α7nAChR/JAK2 signaling pathways.

Shuang Xu,Lang Guo,Weijing Shao,Licai Liang,Tingting Shu,Yuhan Zhang,He Huang, Guangqi Guo,Qing Zhang,Peng Sun

World journal of emergency medicine（2023）

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摘要

The neuroprotective effect of VNS correlated with the activation of α7nAChR. VNS may alleviate cerebral IR injury by inhibiting TLR4/NF-κB and activating the α7nAChR/JAK2 signaling pathway.

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关键词

Cardiopulmonary resuscitation,Vagus nerve stimulation,Inflammation,Toll-like receptor 4,α7 nicotinic acetylcholine receptor

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