Fetal hypoxia expose caused autophagy in ovary granulosa cells via PI3K/Akt/FoxO1 pathway and mitigated by melatonin Subheading.

Luyao Zhang,Kexiong Liu,Zhiqiang Liu,Haiping Tao,Xiangwei Fu,Jian Hou,Gongxue Jia,Yunpeng Hou

Journal of advanced research（2023）

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摘要

Our data found that fetal hypoxia causes ovarian GCs excessive autophagy leading to low fertility in neonatal female mice and mitigated by melatonin. These results provide a potential therapy for hypoxic stress-related reproductive disorders.

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