The relationship between the intestinal microbiome and body mass index in children with cystic fibrosis

Rachel Bernard,Meghan H. Shilts,Britton A. Strickland,Helen H. Boone,Daniel C. Payne,Rebekah F. Brown,Kathryn Edwards,Suman R. Das,Maribeth R. Nicholson

Journal of Cystic Fibrosis（2023）

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摘要

•The long-term outcomes and survival of pediatric patients with cystic fibrosis (CF) is linked to their BMI percentile (BMIp).•Children with CF have reduced gut microbiome diversity and richness when compared to healthy children.•Gut microbiome richness and alpha-diversity is lowest in those children with CF with the lowest BMIp.•Butyrate-producing bacteria are significantly reduced in patients with CF with the lowest BMIp.

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关键词

Cystic fibrosis (CF),Body mass index (BMI),Microbiome,Gut,Nutrition

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