Mild traumatic brain injury induces pericyte detachment independent of stroke vulnerability

Bailey Whitehead,Deborah Corbin,Ali Albowaidey,Ning Zhang,Kate Karelina,Zachary M. Weil

Neuroscience Letters（2024）

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摘要

•Mild closed head injury induces pericyte detachment away from cerebrovasculature.•mTBI-induced pericyte detachment persists over time at least two weeks post-injury.•mTBI causes worsened ischemic stroke outcomes.•Pharmacological pericyte detachment does not replicate these stroke outcomes.

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关键词

Traumatic brain injury,Pericytes,Cerebrovasculature,Ischemia

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