Pinpointing the contributors to myocardial passive stiffness
Nature Cardiovascular Research(2023)
摘要
The key determinants of the passive mechanical properties of the heart have long been debated, but remain controversial. Research using a precision approach indicates that titin, microtubules, actin and the extracellular matrix each meaningfully contribute to myocardial passive stiffness in a highly context-dependent manner.
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