Deep eutectic solvents in sample preparation and determination methods of pesticides: Recent advances and future prospects

This review summarizes recent advances of deep eutectic solvents (DESs) in sample preparation and determination methods of pesticides in food, environmental, and biological matrices since 2019. Emphasis is placed on new DES categories and emerging microextraction techniques. The former incorporate hydrophobic deep eutectic solvents, magnetic deep eutectic solvents, and responsive switchable deep eutectic solvents, while the latter mainly include dispersive liquid-liquid microextraction, liquid-liquid microextraction based on in-situ formation/decomposition of DESs, single drop microextraction, hollow fiber-liquid phase microextraction, and solid-phase microextraction. The principles, applications, advantages, and limitations of these microextraction techniques are presented. Besides, the use of DESs in chromatographic separation, electrochemical biosensors, fluorescent sensors, and surface-enhanced Raman spectroscopy are discussed. This review is expected to provide a valuable reference for extracting and detecting pesticides or other hazardous contaminants in the future.