New thiosemicarbazones and their palladium(II) complexes: Synthesis, spectroscopic characterization, X-ray structure and anticancer evaluation

Wycliffe Odhiambo Misigo,Lydia Wanjiru Njenga,Ruth Akech Odhiambo,Mervin Meyer, Lauren Julius, Nicole Sibuyi,Roger A. Lalancette,Martin Opiyo Onani

INORGANICA CHIMICA ACTA（2023）

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摘要

•Ligands synthesized in ethanolic solutions resulted in high yields.•Synthesis of Pd-complexes (C1,C2andC3) via Pd(COD)Cl2 resulted to high yields > 90%•Complex C3 had selective anticancer activities.•All the cell lines were highly susceptibletoL1.

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关键词

Cancer,Palladium complexes,Thiosemicarbazone,Cytotoxicity,Schiff bases

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