Biological potential of vinyl/allyl substituted imidazole-based N-heterocyclic carbene adducts: synthesis, spectral and X-ray crystallographic structural characteristics

This manuscript describes the synthesis of three new selenium vinyl/allyl adducts (IV-VI), which incorporate imidazolium- N-heterocyclic carbene salts (I-III) are. The characterization was carried out using NMR spectroscopy and elemental analysis. Particularly, for adduct IV, its structural elucidation was further validated through X-ray diffraction. The vinyl/allyl compounds (I-VI) were evaluated toward two different bacterial strains Escherichia coli and staphylococcus aureus. Salt III shows a MIC = 62.5 mu g/ mL and its respective adducts VI shows MIC = 31.2 mu gmL(-1) against Escherichia coli. All the compounds (I-VI) exhibited significant efficacy against S. aureus with MIC value in the range of 31.2-250 mu gmL(-1). The highest activity is shown by compound VI i-e 31.2 mu g/ mL. All the compounds (I-VI) have thrombolytic potential (65.2 +/- 0.89-88.2 +/- 0.11%), suggesting their viability as effective agents for thrombolysis. Hemolysis showed cytotoxicity in the range of 2.87 +/- 0.12 to 5.49 +/- 0.28% which demonstrated they have not injurious effect on health and thus safe.