Non-enzymatic electrochemical sensor based on Pt/MoSe₂ nanomesh for the detection of hydrogen peroxide

The development of diagnostic methods that are sensitive and selective for detection of reactive oxygen species (ROS) is crucial for early diagnosis of bladder cancer. Herein, a new electrochemical sensing platform for hydrogen peroxide (H2O2) was created based on the Pt/MoSe2 nanomesh with more active sites and larger specific surface area. The Pt/MoSe2 nanomesh sensors exhibited highly sensitive and selective for H2O2, wherein the correlation coefficient (R-2) and the limit of detection (LOD) were 0.9983 and 2.56 mu M obtained at the signal/noise (S/N) ratio of 3, respectively. Additionally, Pt/MoSe2 nanomesh possessed a good anti-interference performance even in the presence of potentially interfering small molecules within cells, such as ascorbic acid (AA), glucose (Glc) and so on. More importantly, the detection of H2O2 in tap, rain Water, urine FBS, human serum and bladder cancer T24 cells could be successfully detected by the Pt/MoSe2 nanomesh electrochemical sensor.