Home Diagnosis of Myocardial Infarction: Aptamer-Based cTnI Sensing Technology

Cardiac troponin I (cTnI) is a biomarker closely associated with acute myocardial infarction (AMI ) and is considered as the " gold standard" for the diagnosis of AMI. A variety of cTnI detection techniques have been developed, including antibody-based and aptamer-based detection methodology. Aptamers are short DNA or RNA sequences that can specifically bind to the target, and have been used in the development of cTnI detection platforms due to their advantages of good stability, easy synthesis and low cost. In this paper, cTnI detection methods are divided into optical detection and electrochemical detection according to the signal transduction mode. This review introduces the current research progress of aptamer-based cTnI sensing technology, describes the detection principle, performance, advantages and disadvantages of various methods, summarizes cTnI sensing technology and prospects its development in home testing, hoping to provide reference for the development of more sensitive and portable cTnI sensors.