Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies

Nadav Furie,Michal Mandelboim,Neta Zuckerman,Ana Belkin, Lior Seluk,Inbal Shafran, Ronen Mass,Liran Levy, Sumit Chatterji,Erik Baltaxe,Michael Peled,Tiberiu Shulimzon,Abraham Avigdor,Sharon Amit,Amir Onn,Edith M. Marom,Galia Rahav,Michael J. Segel

OPEN FORUM INFECTIOUS DISEASES（2023）

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摘要

We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.

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antibody therapy, COVID19, immune globulins, monoclonal antibody, SARS-CoV-2

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