Combination of sacubitril/valsartan and blockade of the PI3K pathway enhanced kidney protection in a mouse model of cardiorenal syndrome.

Shunichiro Tsukamoto,Hiromichi Wakui,Tatsuki Uehara, Yuka Shiba,Kengo Azushima,Eriko Abe,Shohei Tanaka,Shinya Taguchi,Keigo Hirota,Shingo Urate,Toru Suzuki,Takayuki Yamada,Sho Kinguchi,Akio Yamashita,Kouichi Tamura

European heart journal open（2023）

引用 0|浏览0

暂无评分

摘要

PI3K pathway activation has been identified as a key mechanism affecting remnant kidney injury under ARNI treatment in CRS pathology, and blockading the PI3K pathway with simultaneous ARNI treatment is a potential therapeutic strategy for treating CRS with overt albuminuria.

查看译文

关键词

cardiorenal syndrome,sacubitril/valsartan,kidney

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要