Pathophysiological Sex Differences in Heart Failure Progression After Acute Coronary Syndrome: Insights From the EXAMINE Trial

•This research investigates sex-specific differences in the development and progression of heart failure in individuals with type 2 diabetes after acute coronary syndrome.•Interleukin-6 emerges as a central factor in the pathogenesis of heart failure, representing a potential therapeutic target applicable to both sexes.•Elevated levels of specific circulating proteins related to immunological pathways in female heart failure patients provide valuable insights into the distinctive pathophysiological mechanisms underlying heart failure progression.