Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant.

June-Wha Rhee,Raju Pillai, Tianhui He,Alysia Bosworth,Sitong Chen,Liezl Atencio,Artem Oganesyan,Kelly Peng,Tati Guzman,Kara Lukas,Brianna Sigala,Aleksi Iukuridze,Lanie Lindenfeld,Faizi Jamal,Pradeep Natarajan,Scott Goldsmith,Amrita Krishnan, Michael Rosenzweig,F Lennie Wong,Stephen J Forman,Saro Armenian

JAMA cardiology（2023）

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摘要

CHIP was significantly and independently associated with risk of CVD in patients with MM undergoing HCT and may serve as a novel biologically plausible biomarker for CVD in this cohort. Patients with MM and both CHIP and cardiovascular risk factors had an exceptionally high risk of CVD. Additional studies are warranted to determine if cardiovascular preventive measures can reduce CHIP-associated CVD risk.

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