Backbone assignment of the intrinsically disordered N-terminal region of Bloom syndrome protein
JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY(2023)
摘要
Bloom syndrome protein (BLM) is a pivotal RecQ helicase necessary for genetic stability through DNA repair processes. Our investigation focuses on the N-terminal region of BLM, which has been considered as an intrinsically disordered region (IDR). This IDR plays a critical role in DNA metabolism by interacting with other proteins. In this study, we performed triple resonance experiments of binding partners using NMR.
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关键词
Bloom syndrome protein, backbone assignment, intrinsically disordered region
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