Plasmonic optical fiber meta-tip for cancer biomarkers detection

Sensors based on Lab-On-Tip (LOT) technology, where suitably designed nanostructures are integrated onto the end face of an optical fiber, are of strategic importance especially in medicine and clinical diagnostics, where miniaturization and portability are key characteristics. To improve the performance of LOT biosensors, we proposed the integration of the optical fiber with plasmonic Metasurfaces (Optical fiber meta-tip, OFMT), sensibly enhancing the light-matter interaction. Here we report on the remarkable capabilities of plasmonic OFMTs to perform label-free detection of cancer biomarkers with improved performances with respect to state-of-the-art optical fiber sensors.