Anti-angiogenic Potential of Trans-chalcone in an In Vivo Chick Chorioallantoic Membrane Model: An ATP Antagonist to VEGFR with Predicted Blood-brain Barrier Permeability.

Anna Senrung,Tanya Tripathi,Nikita Aggarwal,Divya Janjua,Arun Chhokar,Joni Yadav,Apoorva Chaudhary,Kulbhushan Thakur,Tejveer Singh,Alok Chandra Bharti

Cardiovascular & hematological agents in medicinal chemistry（2023）

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摘要

The present study showed TC to possess anti-angiogenic potential via the inhibition of VEGFR-2. In addition, the study predicted TC to cross BBB as well as a safe alternative for GBM therapy, which needs further investigation.

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atp antagonist,anti-angiogenic,trans-chalcone,blood-brain

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