Micro-RNA content of circulating extracellular vesicles in early rheumatoid arthritis as biomarkers and mediators of methotrexate efficacy.

Daniel Maunder,Philip M Brown,Ben Barron-Millar,Dennis W Lendrem,Najib Naamane,Jamie Macdonald,Xiao N Wang,John D Isaacs,Amy E Anderson,Ann W Morgan,Rachel E Crossland,Sarah L Mackie,Arthur G Pratt

Rheumatology (Oxford, England)（2023）

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摘要

Our data highlight the potential of serum EV miRs as diagnostic and therapeutic biomarkers, highlighting a novel potential mechanism via which MTX may exert its therapeutic effect in early RA that warrants further investigation.

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