876 Self-replicating RNA therapeutics for off-the-shelf precision immunotherapy targeting acquired resistance mutations in low TMB tumors

Erika J Crosby,Zachary C Hartman,Annie Chou,Christine Domingo,Jessica Sparks,Zelanna Goldberg, Darina Spasova, Christian Maine, Gabrielle P Dailey, Gaelle Picarda, Hunter Little,Shigeki Miyake-Stoner, Christopher A Rabiola, Herbert K Lyerly, Nathaniel Wang,Parinaz Aliahmad

Journal for ImmunoTherapy of Cancer（2023）

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rna therapeutics,resistance mutations,immunotherapy,self-replicating,off-the-shelf

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