Recombinant Methioninase Lowers the Effective Dose of Regorafenib Against Colon-Cancer Cells: A Strategy for Widespread Clinical Use of a Toxic Drug.

Brad Barsam Choobin,Yutaro Kubota,Qinghong Han,Daniel Ardjmand,Sei Morinaga,Kohei Mizuta,Michael Bouvet,Takuya Tsunoda,Robert M Hoffman

Cancer diagnosis & prognosis（2023）

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摘要

rMETase and regorafenib are synergistic, giving rise to the possibility of lowering the effective dose of regorafenib in patients, thereby reducing its severe toxicity, allowing more cancer patients to be treated with regorafenib.

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colon-cancer colon-cancer cells,colon-cancer colon-cancer,effective dose,regorafenib

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