Effect of PCSK9 inhibition on plasma levels of small dense low density lipoprotein-cholesterol and 7-ketocholesterol

Tahir Mahmood,Joshua R. Miles,Jessica Minnier,Hagai Tavori,Andrea E. DeBarber,Sergio Fazio,Michael D. Shapiro

Journal of Clinical Lipidology（2023）

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摘要

•PCSK9 inhibition dramatically reduces both LDL-C and sdLDL-C to a similar degree.•Plasma 7-ketocholesterol levels were not significantly modulated by PCSK9 inhibition.•Changes in 7-ketocholesterol and VLDL-C after PCKS9 inhibition significantly correlated.•7-Ketocholesterol may be carried by VLDL and lost during LDL formation.

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关键词

Atherosclerotic cardiovascular disease,7-ketocholesterol,Low-density lipoprotein,Oxidized lipids,Oxidized low-density lipoprotein,Oxysterols,Proprotein convertase subtilisin/kexin type 9,Small dense low-density lipoprotein,Triglycerides,Very low-density lipoprotein

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