Chemical composition, in vitro and in silico approaches of the relaxant effect of the jejunum using Thymus algeriensis Boiss. and Reut essential oil

•Thujone dominates the composition of Thymus algeriensis essential oil (TaEO).•TaEO did not produce any observable signs of toxicity or mortality at 1 g/Kg.bw.•TaEO exhibit a dose-dependent myorelaxant effect on the rabbit jejunum contractions.•TaEO induced an antispasmodic effect on KCl and CCh induced contractions.•Thujone could bind to the active site of calcium channel and muscarinic receptor.