(E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol alleviates inflammatory responses in LPS-induced mice liver sepsis through inhibition of STAT3 phosphorylation

Boyoung Kim,Ji Eun Yu,In Jun Yeo,Dong Ju Son,Hee Pom Lee,Yoon Seok Roh, Key-Hwan Lim,Jaesuk Yun,Hanseul Park,Sang Bae Han,Jin Tae Hong

International Immunopharmacology（2023）

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摘要

•MMPP enhances the survival rate of LPS-induced liver sepsis mice model.•MMPP reduces the expression of iNOS, COX-2, and secretion of inflammatory cytokines.•MMPP prevents LPS-induced STAT3 phosphorylation.•MMPP alleviates liver sepsis through STAT3 inhibition.

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关键词

Sepsis,STAT3,LPS,Cytokines,MMPP

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