C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies

•In erythroid cells, ZNF410 regulates a single target gene, CHD4, encoding a NuRD complex component.•Selective glue degraders have been developed for members of IKAROS family of ZF proteins.•A highly selective and non-genotoxic histone H3 lysine 9 methyltransferase G9a inhibitor induces fetal globin expression in both human erythroid cells and mice.•Non-nucleoside, dicyanopyridine-containing DNMT1-selective inhibitors/degraders have shown promising therapeutic potential in a transgenic mouse model of sickle cell disease.